Genea stands at the forefront of fertility technology, offering pioneering services such as IVF, ICSI, and Preimplantation Genetic Testing (PGT). Since launching the first chromosome screening of embryos in 1996 and introducing testing for inherited single gene disorders in 1998, Genea has led the way in maximizing potential outcomes for aspiring parents. With integrated IVF and genetic facilities on-site, Genea offers a comprehensive approach to fertility, enhancing the chances of a healthy pregnancy and birth.

PGT-A is a crucial process performed at our fertility center, where embryos, either naturally conceived or created via IVF, are tested for the correct number of chromosomes. This testing helps to reduce risks associated with genetic abnormalities, such as miscarriages or conditions like Patau syndrome (Trisomy 13) and Edward syndrome (Trisomy 18), especially recommended under circumstances like:

• Previous pregnancies impacted by chromosomal abnormalities
• Maternal age over 35
• History of recurrent miscarriages
• Multiple unsuccessful embryo transfers

At Genea, Preimplantation Genetic Testing for Monogenic Conditions (PGT-M) offers a proactive approach for couples undergoing IVF. This genetic test is specifically designed to detect single gene disorders in embryos, allowing for informed decisions in family planning. Suitable for embryos at the right developmental stage, a meticulous process involves extracting a small number of cells for detailed genetic analysis.

PGT-M is particularly effective for individuals with a known risk of passing specific genetic disorders onto their children. The test covers a broad spectrum of both common and rare genetic conditions, including cystic fibrosis, thalassemia, and Huntingtons disease. Our experienced Genea PGT Scientists utilize advanced techniques to provide accurate assessments, making PGT-M a valuable option for many couples. This test is especially recommended if:

• You or your family have a history of a genetic disorder.
• One or both partners are carriers of a genetic condition that might affect a childs health, such as spinal muscular atrophy or fragile X syndrome.

Its important to note that PGT-M cannot detect all genetic conditions, particularly if the genetic underpinning of a disorder is unknown.

PGT-SR is another specialized genetic test offered at Genea, designed to identify embryos with balanced chromosomal arrangements. This test is crucial for individuals known to have balanced chromosomal translocations or inversionsconditions where the chromosome number is correct, but the arrangement is altered.

People with balanced chromosomal rearrangements typically do not exhibit health issues themselves, but they have a higher risk of creating embryos with unbalanced chromosomal information, leading potentially to miscarriages or significant developmental disorders in children. PGT-SR aims to select embryos that have a balanced chromosomal setup, thereby greatly improving the chances of a successful pregnancy and a healthy baby. This testing is vital under the following circumstances:

• You have been diagnosed with a balanced chromosomal rearrangement.
• You are concerned about the potential for chromosomal issues affecting your pregnancy outcome.

By opting for PGT-SR, you can significantly increase the probability of a healthy ongoing pregnancy, as only chromosomally balanced embryos are chosen for transfer.

Have questions about Pre-implantation Genetic Testing (PGT)? Contact our Fertility Concierge team for answers and support.

To initiate the process for PGT-M or PGT-SR, prospective parents should consult with their fertility specialist at our fertility center. The specialist assesses the medical and familial history to determine the appropriateness of PGT for the individual's situation. For those considering PGT-A (formerly PGS), typically, the fertility specialist will decide its necessity based on detailed reproductive histories and refer the individual to Geneas pathology department for testing.

Genea is committed to providing comprehensive fertility solutions and support, utilizing the latest in genetic testing and IVF technology to facilitate the journey towards parenthood. Our dedicated team of fertility specialists and geneticists ensures that each couple receives tailored advice and treatment plans, aimed at achieving the best outcomes for them and their future families.